Psychiatrists call it the "trial and error factor": when they set out to prescribe an antidepressant, they have no clinically proven way of knowing which one to ...

Cytochrome P450 Defects Linked to Opioid Regimen Efficacy Most patients with multiple defects of the cytochrome P450 system naturally gravitated toward an opioid regimen primarily metabolized through ...

Alexis Garcia, PharmD, senior director of business development at Tabula Rasa HealthCare, outlines how cytochrome P450 enzymes can impact medication efficacy in patients taking multiple drugs. So the ...

This statement summarizes the Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group recommendations regarding CYP450 genetic testing in adult patients beginning treatment ...

Aim: The present study aimed to investigate the human genetic diversity of the CYP450 superfamily in order to identify functional interethnic differences and analyze the role of CYP450 enzymes in ...

Phase I study of docetaxel and temsirolimus in refractory solid tumors. Background: Interactions of cytochrome P450 (CYP), especially CYP3A4, between chemotherapy agents and other xenobiotics can ...

Cytochrome P450 proteins (CYP450s) are membrane-associated haem proteins that metabolize physiologically important compounds in many species of microorganisms, plants and animals. Mammalian CYP450s ...

Please provide your email address to receive an email when new articles are posted on . The majority of drug interactions today are attributed to the cytochrome P450 (CYP450) isoenzyme system. However ...

Pharmacokinetic drug-drug interactions (DDIs) involving opioid analgesics can be problematic. Opioids are widely used, have a narrow therapeutic index, and can be associated with severe toxicity. The ...

Laboratory Corporation of America ® Holdings (LabCorp ®) has announced the availability of Roche Diagnostics' Cytochrome AmpliChip™ P450 2D6/2C19 Genotyping and Phenotyping Assay as an enhancement to ...

A number of studies have highlighted that ethnicity is an important factor influencing the genetic variability of some CYP450 enzymes and that human adaptation could have a role in shaping the genetic ...