Sept. 16, 2003 — St. John's wort increases metabolism via the cytochrome P450 (CYP) enzyme system 3A4, according to the results of a study published in the Sept. 17 issue of The Journal of the ...
Purpose: Osteosarcoma, the most common pediatric primary bone tumor, is an aggressive malignancy with a tendency for early pulmonary metastasis. A reliable biomarker to predict clinical outcome at ...
Tumor control and objective responses: single-center experience with ecteinascidin-743 (ET-743), an active compound for the treatment of patients with advanced soft tissue and bone sarcomas No ...
Please provide your email address to receive an email when new articles are posted on . Older adults taking a statin that is not metabolized by cytochrome P450 3A4 were at greater risk for adverse ...
Cytochrome P450 enzymes are of potential importance in the aetiology and treatment of breast cancer due to their involvement in the activation and/or degradation of carcinogens, steroid hormones as ...
Ann Arbor, MI - The antiplatelet action of clopidogrel appears to be inhibited by the lipid-lowering agent atorvastatin, according to a new study. The authors note that the mechanism involved is ...
Considerable data support the use of statins for the prevention of atherosclerotic cardiovascular diseases.1 An estimated 25 million patients worldwide are taking a statin,1, 2 and according to the US ...
Astex Grants Cytochrome P450 License to Glaxosmithkline CAMBRIDGE, April 24, 2007 -- Astex Therapeutics today announced that it has granted a non-exclusive, worldwide license to its cytochrome P450 ...
Pharmacokinetic drug-drug interactions (DDIs) involving opioid analgesics can be problematic. Opioids are widely used, have a narrow therapeutic index, and can be associated with severe toxicity. The ...
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