A molecule known as anaplastic lymphoma kinase (ALK) is a driver of several cancers, including pediatric neuroblastoma, B-cell lymphomas, and myofibroblast tumors. But for years much about this ...

Chinese Medical Journals Publishing House Co., Ltd. Brain cancer is one of the most aggressive and life-threatening diseases, with glioblastoma (GBM) being the most common and deadliest type. Patients ...

Nuclear receptors are ligand-activated transcription factors that bind to certain DNA regulatory elements in the promoter or vicinity of target genes that lead to transcriptional activation or ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

TAM receptors are key in immune regulation and inflammation resolution, with Axl and MerTK offering protective benefits in RA, while Tyro3 may worsen inflammation. Soluble TAM receptors (sTAMs) could ...

An internationally recognized leader in molecular pharmacology and neurobiology, Dr. Bohn recently joined USF Health. She is ...

A team of researchers has successfully created more effective immune cells that can fight cancer without damaging healthy tissue. "This story goes back nearly 20 years," says Prof. Paul François. This ...

The ancient biochemical 5-hydroxytryptamine—also known as 5-HT and serotonin—has been controlled through evolution to be used widely across the plant and animal kingdoms. 5-HT is used by mammals as a ...

The body has 25 types of functional bitter taste receptors, but tasting is not their only function. Research has shown these receptors also exist in the gastrointestinal tract and on the cells of ...