Small-molecule inhibitors of enzymes can, in principle, treat human disease. But first, researchers must confirm that an inhibitor actually binds its enzyme target in animal experiments. This can be a ...

Reversible inhibition of enzyme, an activity in which the inhibiting molecular entity (often a small chemical called ligand or inhibitor) can associate and dissociate from the protein's binding site, ...

As scientists race to discover new and effective antiviral drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many novel approaches are being utilized. Now, a new study ...

For a class of drugs once treated with trepidation, things are looking up for covalent irreversible kinase inhibitors, which are basking in the glow of US Food and Drug Administration (FDA) approval ...

Researchers describe slow-binding inhibition of cholinesterases and present their pharmacological advantages over classical reversible inhibitors (e.g. long target-residence times, resulting in ...