Despite Phase 2 Strike-Out, New Tau Antibodies Step Up to Plate
More Antibodies take aim at seeded propagation. New data ties tangle location to deficits in specific cognitive domains. Three first-in-human studies for antibodies targeting different parts …
ALS or Alzheimer’s? Blood Phospho-Tau Could Mean Either
Apr 11, 2025 · Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease Plasma phosphorylated tau 217 and phosphorylated tau 181 as …
After Tau Immunotherapy, Tangle Markers Tank in CSF, Plasma
6 days ago · In a small, open-label trial in people with mild to moderate, dominantly inherited Alzheimer’s disease (DIAD), the tau immunotherapy etalanetug almost abolished markers of …
Tau (PHF-1) | ALZFORUM
Feb 5, 2024 · PHF-1 reacts with tau phosphorylated at serine-396 and serine-404. Western blot of recombinant human tau phosphorylated in vitro with GSK3β, probed with PHF-1. WT, wild …
LY3954068 | ALZFORUM
Nov 25, 2024 · LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau. No information is available about the makeup of …
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
Feb 1, 2025 · To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time. It showed that ApoE3Ch clings onto tau …
Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
Dec 29, 2022 · In the December 27 Brain, Karikari reported that plasma concentration of these brain-derived forms of tau (BD-tau) tracked with cerebrospinal fluid markers of amyloid …
Cell-Based Assay Matches Tau Strains to Neuropathological …
Jan 30, 2025 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains. …
Tau (CP-13) - ALZFORUM
Feb 7, 2024 · This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202. Recognizes tau …
JNJ-64042056 | ALZFORUM
In both wild-type C57BL/6 and P301L mutant tau transgenic mice, a three-month regimen of subcutaneous ACI-35 injection rapidly generated high titers of polyclonal IgG antibodies …